To calculate the mass of the Moon, the radius and acceleration due to gravity are key parameters. The Moon's radius is approximately one-third of Earth's, and its gravity is one-sixth that of Earth's. Using the formula for gravitational acceleration, g = GM/R², one can derive the Moon's mass as a fraction of Earth's mass without needing the exact mass of Earth. It's essential to set up the problem with the relevant equations to find the solution effectively. Memorizing the mass of Earth may not be necessary if the problem is approached correctly with the given ratios.