Kinetic energy (KE) cannot be negative since mass is always positive and velocity squared eliminates any negative values. In contrast, gravitational potential energy can be negative based on the chosen reference point for zero potential. However, the critical aspect is that only changes in potential energy affect kinetic energy and the forces involved. Therefore, while KE is always non-negative, gravitational potential energy can vary depending on the system's reference frame. Understanding these principles is essential for analyzing energy transformations in physical systems.