No I disagree it doesn't holds for systems where the total mass of system is variable. Take the example of
@haruspex with a cart that is dripping water. If we take as a system only the cart and not the water that escapes , then if we apply Newton's second law we ll find (due to the term ##\dot m v##, ##F=0\Rightarrow m\frac{dv}{dt}+\frac{dm}{dt}v=0##) that the cart is accelerating, but the water is just dripping so it doesn't carry additional momentum, so where does the extra momentum of the cart is coming from. We have violation of conservation of momentum and also of conservation of energy.
If we consider as system the cart + the water that is dripping then the law holds but then the total mass of this system is constant.