To derive the logic equation from a Karnaugh map of an RS flip-flop, one must analyze the map to identify the groupings of 1s that correspond to the outputs. The discussion highlights confusion regarding the representation of outputs, specifically the relationship between the previous output "q" and the current output "Q." Participants seek clarification on how to interpret the truth table in relation to the Karnaugh map. Understanding these relationships is crucial for accurately forming the logic equation. The conversation emphasizes the importance of clear definitions in digital logic design.