We've known for a long time that we humans share common ancestry with the other great apes—gorillas, orangs, chimps, and bonobos. But there's an interesting problem here. We humans have 46 chromosomes; all the other great apes have 48. In a sense, we're missing a pair of chromosomes, two chromosomes. How did that happen?
Well, is it possible that in the line that led to us, a pair of chromosomes was simply lost, dropping us from 24 pairs to 23? Well, the answer to that is no. The loss of both members of a pair would actually be fatal in any primate. There is only one possibility, and that is that two chromosomes that were separate became fused to form a single chromosome. If that happened, it would drop us from 24 pairs to 23, and it would explain the data.
Here's the interesting point, and this is why evolution is a science. That possibility is testable. If we indeed were formed that way, then somewhere in our genome there has to be a chromosome that was formed by the fusion of two other chromosomes. Now, how would we find that? It's easier than you might think.
Every chromosome has a special DNA sequence at both ends called the telomere sequence. Near the middle it has another special sequence called the centromere. If one of our chromosomes was formed by the fusion of two ancestral chromosomes, what we should be able to see is that we possesses a chromosome in which telomere DNA is found in the center where it actually doesn't belong, and that the chromosome has two centromeres. So all we have to do is to look at our own genome, look at our own DNA, and see, do we have a chromosome that fits these features?
We do. It's human chromosome number 2, and the evidence is unmistakable. We have two centromeres, we have telomere DNA near the center, and the genes even line up corresponding to primate chromosome numbers 12 and 13.