To find the unknown resistance R2 in a series circuit with known values of R1, R3, and E, the same current flows through all resistors. The voltage equation, v1 + v2 + v3 = E, can be used to isolate v2, which relates to R2 and the current I. However, without the value of I or R2, it's impossible to determine a unique solution; multiple values can satisfy the equations. The discussion suggests trying different values for R2 to explore potential solutions or contradictions in the problem. Ultimately, the lack of specific values for I or R2 means that only symbolic solutions can be derived.