To solve the equation e^x + e^{3x} - 1 = 0, the substitution y = e^x transforms it into the cubic equation y^3 + y - 1 = 0. The discussion reveals that there is one real solution and two complex solutions to this cubic equation. Participants express confusion about the possibility of x equating to zero, as substituting x = 0 leads to a contradiction. The conversation emphasizes the complexity of finding the real solution and suggests consulting resources like Mathworld for further guidance on cubic equations. Ultimately, the cubic function's nature indicates that solutions may not be straightforward.