Here's what popped into my head when I read your title:
There is this idea regarding the higgs (there's actually an arxiv paper I think, but I just grabbed the first thing google gave me on this)
http://www.newscientist.com/blogs/shortsharpscience/2009/10/is-a-time-travelling-higgs-sab.html
Roughly: the Higgs particle is so "abhorred" by nature, that nature essentially will do astronomically improbable things to prevent its creation. To make the idea subject to the "scientific method" a scientist suggested the following experiment: when the LHC is all ready to go: have a random number generator produce a huge random string, and decide ahead of time a particular number that means no scientist will flip the "on" switch for particle collisions. If the number repeatedly gets chosen beyond all statistical reasonability, it is a scientific test of this idea.
Now, for even more fun, after this was suggested, this happenned (which is why this popped in my head from "accident at the LHC"):
http://www.guardian.co.uk/science/2009/nov/06/cern-big-bang-goes-phut
the most ridiculous way to shut down the LHC!
(again, first thing google gave, I didn't even read it. So there may be a better source)
So now add in some "extrapolation" and fiction. There are so many options! And using real news to get it started will be fun for those that are unknowning start to look into it.
Example extrapolation and fiction practically "madlibs" style!
A scientist starts to take the joking idea very seriously, but feels he can't tell anyone for fear of being laughed at. He starts doing little experiments like: "i'll sabotage this, if and only if such and such happens" ... it keeps happenning. Eventually he realizes he can use this machine, and this property of it, to essentially make his own wish granting machine!
He starts small at first, not sure how high in "unlikelyness" for each wish he can actually make. Eventually people start getting hint that he is a saboture (but they don't know the reason why) so in the background you can also have a great crime investigation and cover up story going.
Culminating to ... a conspiracy theory that the government _knew_ this would become a wish granting machine. So some government spies know what he's up to (more than just sabotaging) and come after him.
Final twist ... his life is becoming ruined, and he's getting cornered in his options. So he makes the final wish that there is peace on Earth and all will be forgiven. The irony is that this is too unlikely ... the event doesn't happen, so while he waits to do the sabotage, the particle collisions go on and a higgs particle actually is created ... then nature destroys the Earth to get rid of it.
The end.