To obtain the equation for the line of best fit in Excel, users can utilize the "least squares" method for polynomial fitting, with options available up to the sixth order, as well as exponential curves. After plotting the data points on an XY-scatter chart, adding a trendline through the chart properties allows for visual representation. To display the equation of the trendline, users must check the appropriate box in the Options tab. For a more precise calculation, the LINEST function can be employed, requiring the input of x and y data ranges along with parameters for intercept and statistics. This function must be entered as an array formula by selecting a 3x2 block of cells and using Ctrl+Shift+Enter. Additionally, users are encouraged to explore Excel's help system for further guidance on array formulas and the LINEST command.