Peptide Bond Dissociation Temperaure

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    Bond Dissociation
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The discussion centers on the energy required to break peptide bonds without catalysts. Peptide bond dissociation energies range from 8 to 10 kJ/mol, while room temperature provides about 2.5 kJ/mol of energy. Despite this, peptide bonds are notably resistant to hydrolysis under typical conditions, necessitating high temperatures (around 250°C) or harsh environments for effective hydrolysis. The Arrhenius equation is referenced to explain the relationship between temperature and reaction rates in this context.
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This is more of a biochem question, but since there is not biochem forum, I'll ask it here.

How much heat is required to break a peptide bond (not just denature the protein) in the absence of any catalysts?
 
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Hello RP, :welcome:

Not much by chemical standards: I found peptide bond dissociation energies are 8-10 kJ/mol.
At room temperature, RT is already about 2.5 kJ/mol.
Check out the Arrhenius equation
 
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