Positive slopes can arise from points (x1, y1) and (x2, y2) under two conditions: both x1 must be less than x2 and y1 must be less than y2, or both x1 and x2 can be greater than their respective counterparts, resulting in a negative slope. The discussion highlights that positive slopes do not exclusively require x1 < x2 and y1 < y2, as the negative-negative case also produces a positive slope. Clarification on the conditions for positive slopes is essential for understanding slope behavior in coordinate geometry. The conversation emphasizes the importance of considering all possible scenarios when evaluating slopes. Understanding these conditions is crucial for accurate mathematical analysis.