Pressure loss in a transmission line can be analyzed using the Darcy-Weisbach equation for major losses due to friction and minor loss coefficients for fittings, which can be found in datasheets or engineering tables. The discussion highlights the need to consider both major and minor losses when assessing pressure loss through components like reducing unions and filters. The impact of oscillation and backflow on pressure loss through a diaphragm is also examined, emphasizing the importance of calculating velocities rather than making assumptions. Additionally, the relationship between pipe diameter and frequency is questioned, suggesting the need for further research and literature review on the topic. Understanding these dynamics is crucial for accurately determining pressure loss in unsteady flow conditions.