Solvents for Grignard Synthesis?

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For conducting Grignard reactions, suitable solvents include tetrahydrofuran (THF), dioxane, and glyme, despite their miscibility with water. The key requirement is that the solvent must not react with Grignard compounds, as any reactive solvent would hinder the reaction. To ensure effectiveness, these solvents should be thoroughly dried, typically achieved by passing them through basic alumina. The primary concern is to avoid any solvent that can interact negatively with the Grignard reagent, as this would compromise the reaction's success.
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Okay so besides anhydrous diethyl ether, what other solvents could I use for a Grignard? What makes it a good solvent and what makes something a bad solvent? I know we want something that isn't miscible with water in the least bit because this would kill the reaction, but what else?

Thanks
 
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Any solvent that can react with Grignard compounds is a bad one...
 
The standard set is tetrahydrofuran, dioxane and glyme (MeOCh2CH2OMe). They are actually all micible with water, you just need to dry them first. Normally (nowadays) that is done by passing them through a short pad of basic alumina.
 

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