1. Limited time only! Sign up for a free 30min personal tutor trial with Chegg Tutors
    Dismiss Notice
Dismiss Notice
Join Physics Forums Today!
The friendliest, high quality science and math community on the planet! Everyone who loves science is here!

Homework Help: Synthesis of aspirin

  1. Nov 24, 2009 #1
    1. The problem statement, all variables and given/known data
    Write the complete mechanism for the acid-catalyzed formation of aspirin from salicylic acid and acetic anhydride

    2. Relevant equations

    3. The attempt at a solution
    I basically know the reaction but i'm not sure how to start the mechanism...Like i know that it is a substitution reaction where the OH group and the CH3--C==O switch places but how does it start? Does the the H group from the OH group first leave, then the CH3--C==O group can attack the O?
  2. jcsd
  3. Nov 28, 2009 #2


    User Avatar
    Science Advisor
    Homework Helper
    Gold Member

    Its a bit like Fisher Esterification.
Share this great discussion with others via Reddit, Google+, Twitter, or Facebook