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Synthesis of aspirin

  1. Nov 24, 2009 #1
    1. The problem statement, all variables and given/known data
    Write the complete mechanism for the acid-catalyzed formation of aspirin from salicylic acid and acetic anhydride

    2. Relevant equations

    3. The attempt at a solution
    I basically know the reaction but i'm not sure how to start the mechanism...Like i know that it is a substitution reaction where the OH group and the CH3--C==O switch places but how does it start? Does the the H group from the OH group first leave, then the CH3--C==O group can attack the O?
  2. jcsd
  3. Nov 28, 2009 #2


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    Its a bit like Fisher Esterification.
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