Difference Between GABA A and GABA B?

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GABA A receptors are chloride ion channels that directly influence the electrophysical properties of neurons, leading to immediate inhibitory effects. In contrast, GABA B receptors activate metabolic pathways through G protein cascades, which modulate neuronal activity by down-regulating adenyl cyclase and shutting down ion reactivity. This distinction highlights the different mechanisms by which GABA receptors exert their effects on neuronal signaling. Understanding these differences is crucial for developing targeted therapies for neurological disorders. The conversation emphasizes the importance of recognizing the functional roles of GABA receptor subtypes in the nervous system.
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Difference Between GABA A and GABA B?
 
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In what sense?

At the molecular level, A receptors are Cl- ion channels, B receptors activate metabolic pathways. So A directly affects electrophysical properties, B affects molecular network dynamics through G protein cascades (which shut down the neuron's ion reactivity and down-regulates adenyl cyclase).
 

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