To calculate the total resistance in a circuit with resistors in series and parallel, it's essential to identify their configuration. The circuit includes resistors of 25k, 15k, 50k, 40k, and 20k Ohms, with the 50k Ohm resistor in parallel with the 40k and 20k Ohm resistors. A clear description of the circuit connections can help in understanding the arrangement without needing a visual aid. The total resistance can be calculated using the formulas for series and parallel resistors. Providing a diagram or a detailed description of the connections can enhance clarity in such discussions.