How do I calculate the profile frequency of a mixed sample?

[Popz]

Homework Statement

This is a DNA sample taken from under the fingernail with a major and minor contributor.

Relevant Equations

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Here an excerpt of my sample. In this case the minor contributors match 100% with a reference sample from a suspect. I am now to calculate the profile frequency to calculate the likelihood ratio.

Do I multiply the allele frequencies of both minor and major contributor and use this value as my genotype frequency?

 

[Asim Riaz]

Sample: Minor ContributorAllele 1: 3Allele 2: 5Major ContributorAllele 1: 14Allele 2: 6Reference Sample: Allele 1: 3Allele 2: 5No, you don't multiply the allele frequencies of both the major and minor contributors to calculate the genotype frequency. The genotype frequency for your sample is the sum of the allele frequencies for the minor contributor (3+5=8) and the major contributor (14+6=20). So, the genotype frequency for your sample is 8 + 20 = 28.