To derive an explicit formula from an integral equation, one must utilize the Fundamental Theorem of Calculus, which states that if F(x) is defined as the integral of f(t) from 0 to x, then F'(x) equals f(x). The discussion highlights that finding an explicit form often requires recognizing the antiderivative of the function involved, which can be challenging as it may involve various integration techniques. It is noted that there is no universal method for all functions, and many approaches are specific to certain cases. Additionally, the conversation touches on the graphical interpretation of the area under a curve and clarifies that F(x) is not a constant function unless the integrand is zero. Understanding these principles is essential for solving integral equations effectively.