The discussion centers on the role of pKa and pKb in predicting the charge of organic compounds at specific pH levels. It is established that pKa and pKb are crucial for understanding acid-base reactions, particularly protonation, and are generally sufficient for predicting charges. The conversation indicates a consensus on the importance of these properties, with no counterexamples presented to challenge their relevance. The participants express satisfaction with this understanding, confirming that pKa and pKb are key indicators in this context.