The tolerance for a pneumatic cylinder and piston operating at 2 psi should allow for a gap to prevent rubbing, which can cause wear and heat. Seals are essential as they create contact stress that can counteract the pressure differential, but some leakage will always occur due to the inherent gap. A very close tolerance can reduce leakage, but it may increase friction, which is influenced by the gap size. For applications like air springs, thermal variations must be considered, and appropriate seals, such as O-rings, should be used to maintain functionality. Proper design is crucial for balancing leakage, friction, and thermal expansion.