To solve Laplace's equation in three dimensions, it is essential to specify the coordinate system, boundary conditions, and desired accuracy of the solution. Common methods include separation of variables, Fourier transforms, and numerical techniques like finite differences. For a rectangular solid with specified boundary conditions, separation of variables can be applied by expressing the solution as a product of functions dependent on each coordinate. The resulting ordinary differential equations can be solved to find a series solution that satisfies the boundary conditions. Additionally, for steady-state heat transfer in a thin disc, the temperature at the center can be determined using Laplace's equation in cylindrical coordinates, considering the average boundary temperature.