Read about crispr | 13 Discussions | Page 1

  1. Ygggdrasil

    New CRISPR-based tool for find-and-replace editing of DNA

    Over the past half decade, researchers have envisioned the CRISPR-Cas9 genome editing system as a way to correct pathogenic mutations in patients, but these reserachers face a number of hurdles in developing the technology for clinical applications. While CRISPR is very efficient at cutting DNA...
  2. Ygggdrasil

    Measuring off target mutations during CRISPR gene editing

    CRISPR gene editing is a newly developed tool that allows researchers to easily make changes to an organism's DNA. There is much interest in using this technology in clinical applications, but there have been major concerns surrounding the safety of the technology, including whether the gene...
  3. Ygggdrasil

    Medical First genetically edited human babies reportedly born

    https://apnews.com/4997bb7aa36c45449b488e19ac83e86d As detailed in the AP news story, most scientists believe the work to be unethical as the safety of the CRISPR gene editing technique used has not yet been fully established. See also...
  4. Ygggdrasil

    The end of mosquitoes?

    Mosquitoes are responsible for spreading a number of human diseases (including malaria, Dengue fever, and Zika virus), and account for nearly half a million deaths per year worldwide. For many years, scientists have been investigating technologies that could help control or even eliminate...
  5. jim mcnamara

    CRISPR and unwanted DNA alterations

    @Ygggdrasil is far more qualified to comment on this than I am, but it seems like a good idea to raise the issue. Published today July 16, 2018 Letter in Nature Biotechnology: https://www.nature.com/articles/Nbt.4192 M. Kosicki, K. Tomberg & A Bradley Abstract: In plain English this says...
  6. TranscedentKid

    Features of CRISPR-Gold?

    Why is gold un-reactive enough to be used as nanoparticles? Why do cells preform endocytosis upon detection of the gold delivery system? What are the chemical receptors active? Why is does it cause less genetic damage than doing it virally? Is this system partly designed to change the DNA of...
  7. Ygggdrasil

    Medical Scientists identify major safety issue with CRISPR

    CRISPR-Cas9 technology provides scientists with an easy way to introduce targeted genetic changes to DNA and a number of different companies are looking at ways to use CRISPR to fix genetic diseases in humans. Two groups of researchers, however, have identified a major issue with CRISPR gene...
  8. Greg Bernhardt

    Gene-edited immune cells could help wipe out deadly tumors

    U.S. Doctors Plan to Treat Cancer Patients Using CRISPR https://www.technologyreview.com/s/609999/us-doctors-plan-to-treat-cancer-patients-using-crispr/
  9. BillTre

    CRISPR Based Base Changes

    CRISPR is often used to switch out a length of DNA for a different piece of sequence, which can change several base pairs at once. Here is a Science news report on how researchers have now developed methods to efficiently change single base pairs in a sequence (or single bases in single...
  10. jim mcnamara

    CRISPR research under scrutiny

    Egli, D. et al. Preprint at http://www.biorxiv.org/content/early/2017/08/28/181255 (2017). A critique of: doi:10.1038/nature.2017.22382 (dated Aug 2) Here is the more news science version of the CRISPR study: https://www.nature.com/news/crispr-fixes-disease-gene-in-viable-human-embryos-1.22382...
  11. Ygggdrasil

    Medical Using CRISPR to cut HIV out of infected cells

    A major impediment to curing patients with HIV is the fact that the virus integrates its DNA into the genome of the cells it infects. While antiretroviral drugs and therapies can prevent infection of new cells and kill cells that are actively producing virus, a "latent reservoir" remains that...
  12. Ygggdrasil

    Medical National Academies Recommendations on Human Gene Editing

    This week on, Feb 14, the US National Academy of Sciences and National Academy of Medicine released a report giving recommendations on how human germline gene editing—making changes to the DNA of humans that are heritable across generations—should be regulated...
  13. F

    Can CRISPR turn a dog into a cat (not at embryo stage)?

    Right I've read all about CRISPR but I can't help to think if such a possibility exists. As far as I know the only way to cause such changes is by modifying cells at the embryo stage. But if crispr can help grow a missing limb or create structural changes at adult stage it does sound like a...
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